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Sequencing the Human Genome

Index of lecture slides:

NOTE: Hover your mouse over a slide number to view a thumbnail of that slide; click the number to view the full-sized slide in a pop-up window. Slide numbers follow Mr. Venter's labels and may not be consecutive..


01

Celera-Sequencing the Human Genome

02

Complementary DNA Sequencing-paper abstract

03

Cover of Science

04

Completed Microbial Genomes-timeline

05

Genomes Sequenced at TIGR and Celera


06

Genesis of Celera August 1998

07

Celera's Sequencing/ SNP Discovery Center

08

Celera Supercomputing Facility

09

NY Times- On Road to Human Genome

10

Obstacles to Genome Sequencing


11

Comparison of Sequencing Strategies

12

Clone by Clone Shotgun Sequencing

13

Mate-Pair Shotgun DNA Sequencing

14

Whole Genome Sequencing Approaches

15

Building Scaffolds


16

3-10 pairs link each consecutive contig

17

Validation against STS-map

18

"Annotation Jamboree"

19

Drosophila genes and their roles-pie chart

20

Cover of Science


21

Haemophilus vs Drosophila

22

Human chromosomes

23

Human Genome Sequence Milestones

24

Dr. Venter at White House, June 2000

25

Cover of Science-The Human Genome


26

Components vs GeneMap '99

27

Order and Orientation is Essential to Finding Genes

28

Scaffold Sizes

29

Gene Number in the Human Genome

30

The Human Genome is NOT...


31

Gene Map

32

Adrenaline Receptor

33

Gene Map

34

Molecular Function of Predicted proteins

35

Mouse Genome Status


36

Mouse/Human Comparison

37

Down Syndrome: Human Mouse Systemy

38

Conservation of Gene Sequence

39

Conservation of Coding Sequence

40

Mouse 16/Human 21 Genetic Schematic Map


41

Linear Schematic of Mouse/Human Data

42

Computed Mouse/Human Orthologs

43

Conservation of Regulatory Signals

44

Nucleotide Differences between Human/Chimpanzee Genomes

45/24

Human vs Chimpanzee Histamine (H1) Receptor


45/25

Human vs Chimpanzee Histamine (H1) Receptor

46

Human proline oxidase gene

47

Large Scale Duplication

48/4

Duplications within the Human Genome (a)

48/5

Duplications within the Human Genome (b)


48/6

Duplications within the Human Genome (c)

48

Duplications within the human genome

49

Genome Duplications in C. elegans

50

Syntenic Blocks between C. elegans and Human

51

Genetic Variation


52

Human Genome Exon and Regulatory Region Resequencing Project

53

Resequencing Program-40 Individuals

54

Human Genome Exon and Regulatory Region Resequencing Project

55

Human Genome Exon and Regulatory Region Resequencing Project-SNPs identified

56/1

CCR5 gene/significant HIV resistance/Caucasians & Blacks


56/2

CCR5 gene/significant HIV resistance/Caucasians vs Blacks

56

Human polymorphisms involved in susceptibility/progression of HIV infection

57

DNA Mismatch Repair

58/4

Molecular Medicine Paradigm (a)

58/7

Molecular Medicine Paradigm (b)

59

Proteomics Factory


60

Proteomics Lab

61

Cancer Specific Vaccines

62/10

Evolving Levels of Information (a)

62/23

Evolving Levels of Information (b)

62

Celera Discovery Sciences



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